Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological Activity1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A chemical switch for inhibitor-sensitive alleles of any protein kinase.
Bishop et al.
Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach.
Bishop et al.
Citations for 1-Naphthyl PP1
The citations listed below are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:
6 Citations: Showing 1 - 6
Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.
Authors: O'Neill Et al.
J Cell Biol 2016;215:217
Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae.
Authors: Meyer Et al.
Genes Dev 2015;26:2986
Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis.
Authors: Chen Et al.
PLoS Biol 2015;13:e1002329
A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture.
Authors: Suhandynata Et al.
G3 (Bethesda) 2014;4:2125
Dual mechanisms prevent premature chromosome segregation during meiosis.
Authors: Kim Et al.
Cell Death Dis 2013;27:2139
Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1.
Authors: Lo and Hollingsworth
Methods Mol Biol 2011;745:135
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