Chemical Name: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
Biological ActivityImatinib mesylate is a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).
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The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.
Buchdunger et al.
Cancer Res., 1996;56:100
Inhibition of c-kit tyrosine kinase by ima. mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis.
Juurikivi et al.
Repurposing of clinically developed drugs for treatment of Middle East Respiratory Syndrome coronavirus infection.
Dyall et al.
Antimicrob.Agents Chemother., 2014;58:4885
Citations for Imatinib mesylate
The citations listed below are publications that use Tocris products. Selected citations for Imatinib mesylate include:
3 Citations: Showing 1 - 3
Long-term imatinib diminishes ovarian reserve and impacts embryo quality.
Authors: Sue A Et al.
J Assist Reprod Genet 2020;37:1459-1466
A Whole Genome-Wide Arrayed CRISPR Screen in Primary Organ Fibroblasts to Identify Regulators of Kidney Fibrosis.
Authors: Hauke Et al.
SLAS Discov 2020;25:591-604
Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.
Authors: So-Youn Et al.
Cell Death Differ 2019;26:502-515
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