17-PA

Key Product Details

Product Description

17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABA_A receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.

Product Specifications for 17-PA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 17-PA

The following data is based on the product molecular weight 350.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.71 mL	28.53 mL	57.05 mL
2.5 mM	1.14 mL	5.71 mL	11.41 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
25 mM	0.11 mL	0.57 mL	1.14 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Akk Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABA_A receptor. Mol.Pharmacol. 2007 PMID: 17105870
• Kelley Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol. Eur.J.Pharmacol. 2007 PMID: 17658511
• Mennerick Selective antagonism of 5α-reduced neurosteroid effects at GABA_A receptors. Mol.Pharmacol. 2004 PMID: 15102947

Product Documents for 17-PA