Designed to Simplify Your Cell Therapy
ProPak GMP cytokines and bagged GMP T cell media were created to help reduce variability and risk in your T cell therapy. GMP IL-2, IL-7, IL-15, and Human T Cell Media are now available in single-use bags, designed to integrate seamlessly into your closed process workflow. IL-2 is available by mass or IU.
View all available ready-to-use protein formats and see how optimal cytokine dosing was determined with data from a cytokine titration study.
View all Ready-to-Use Cytokines
Available Closed Process Reagents |
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| GMP IL-2 | GMP IL-7 | GMP IL-15 | GMP T Cell Media |
Benefits of Closed Process Solutions
Closed System Process
To minimize risk, ProPak GMP cytokines and GMP T cell media bags are designed to integrate seamlessly into a closed system process, mitigating the risk of contamination.
Weldable Tubing
Each bag is outfitted with weldable tubing, so you can connect a ProPak directly to your media bag. Industry standard PVC tubing creates a fully closed cytokine addition step that can then be added to a 1 L bioreactor, such as the G-Rex.
Optimized Performance
After extensive investigation, our scientists identified 10 µg as the optimal dose of IL-2, IL-7, and IL-15 in a 1 L cell culture process. Each single-use ProPak supplies the perfect amount of protein, removing an unwanted source of variability in your process.
Reduced Manual Touchpoints
Removal of reconstitution and aliquot steps leads to less hands-on technician time. This reduces risks of error while streamlining your journey to the clinic.
Ready-to-Use Format
ProPak GMP cytokines can be stored at -20 °C for long term storage* or at 2-8 °C for up to 2 weeks. Accelerated stability testing currently underway to support a 2 year shelf-life at -20 °C.
GMP Human T Cell Media can be stored at 2-8 °C and protected from light, up to the use by date on the Certificate of Analysis.
Customize ProPaks to Fit Your Workflow
Made-to-Order Options:
Fill to your desired protein quantity of IL-2, IL-7, or IL-15
• 10 µg to 1.5 mg
• 150k to 15M IU (IL-2)
• No additional charges for MTO fill or validation
Custom fill with any other GMP cytokine
• See the table below
• Custom validation fees may apply
Have questions, want to order a custom ProPak, or need a protein not on the following list? Contact us with the form below.
GMP Proteins for Custom Fill ProPaks |
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| Activin A | GDF-8/Myostatin | IL-3 | IL-21 | SCF/c-kit Ligand |
| BDNF | GDNF | IL-4 | KGF/FGF-7 | Sonic Hedgehog |
| Betacellulin | HGF | IL-6 | LR3 IGF-1 | TGF-beta 1 |
| BMP-2 | IFN-gamma | IL-7 | M-CSF | Thrombopoietin |
| EGF | IGF-1 | IL-10 | Noggin (Fc tag) | TNF-alpha |
| FGF-basic/FGF2 (Heat Stable) | IL-1 beta | IL-15 | PDGF-AA | VEGF |
| Flt-3 Ligand/FLT3L | IL-2 (IL-2 IU) | IL-18 | PDGF-BB | Wnt-3a |
T Cell Expansion with ProPak Cytokines
ProPak Cytokines Support Robust T Cell Growth
ProPak, liquid, or lyophilized IL-7 and IL-15 were added to Xeno-free GMP Human T Cell Media (Catalog # CCM038-GMP) with 5% huAB Serum. T cells from 3 donors were activated and expanded in G-Rex bioreactors for 9 days and assessed for fold expansion and cell viability. Data is the average of 4 independent experiments with 3 donors per experiment, error bars ± SD.
Connect With Our Experts for Tailored Support
Fill out the form to speak with a local specialist, get technical guidance, or learn how closed systems can be tailored to your workflow needs with our custom capabilities.