3-Nitropropionic acid

Key Product Details

Product Description

3-Nitropropionic acid is an irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.

Product Specifications for 3-Nitropropionic acid

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 3-Nitropropionic acid

The following data is based on the product molecular weight 119.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.40 mL	41.99 mL	83.98 mL
5 mM	1.68 mL	8.40 mL	16.80 mL
10 mM	0.84 mL	4.20 mL	8.40 mL
50 mM	0.17 mL	0.84 mL	1.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Solesio 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 2013 PMID: 22509855
• Huang 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 2005 PMID: 16371358
• de Oca Balderas Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. 2013 PMID: 23643981

Product Documents for 3-Nitropropionic acid