AG 99

Key Product Details

Product Description

AG 99 is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145^met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.

Product Specifications for AG 99

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AG 99

The following data is based on the product molecular weight 204.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.90 mL	24.49 mL	48.98 mL
5 mM	0.98 mL	4.90 mL	9.80 mL
10 mM	0.49 mL	2.45 mL	4.90 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yamamoto Tyrosine phosphorylation of p145^met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J.Cell Sci. 2006 PMID: 17062641
• Gazit Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J.Med.Chem. 1996 PMID: 8960549
• Levitzki and Gilon Tyrphostins as molecular tools and potential antiproliferative drugs. TiPS 1991 PMID: 1862529
• Gazit Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 1989 PMID: 2552117

Product Documents for AG 99