AMI-193
Discontinued Product
Chemical Name: 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone
Purity: ≥99%
Biological Activity
AMI-193 is a selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Behavioural effects of AMI-193, a 5-HT2A- and DA D2-receptor antagonist, in the squirrel monkey.
Czoty et al.
Pharmacol.Biochem.Behav., 2000;67:257 -
Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT2 versus 5HT1C selective antagonist.
Ismaiel et al.
J.Med.Chem., 1993;36:2519
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