Amisulpride

Tocris Bioscience | Catalog # 2132

Selective D2 and D3 antagonist; atypical antipsychotic
Tocris Bioscience
Discontinued Product
2132 has been discontinued. View all Non-selective Dopamine Receptor Antagonists products.

Key Product Details

Description

Selective D2 and D3 antagonist; atypical antipsychotic

Alternative Names

DAN 2163
View all Non-selective Dopamine Receptor Antagonists »

Product Description

Amisulpride is a potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

Product Specifications for Amisulpride

Molecular Weight

369.48

Formula

C17H27N3O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide

CAS Number

71675-85-9

PubChem ID

2159

InChI Key

NTJOBXMMWNYJFB-UHFFFAOYSA-N

SMILES

CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 9.24 25 with gentle warming
DMSO 18.47 50

Preparing Stock Solutions for Amisulpride

The following data is based on the product molecular weight 369.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.41 mL 27.07 mL 54.13 mL
2.5 mM 1.08 mL 5.41 mL 10.83 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for Amisulpride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Amisulpride

For research use only

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