ARN 726

Key Product Details

Product Description

ARN 726 is a potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC₅₀ values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.

Product Specifications for ARN 726

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ARN 726

The following data is based on the product molecular weight 268.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.73 mL	18.63 mL	37.26 mL
5 mM	0.75 mL	3.73 mL	7.45 mL
10 mM	0.37 mL	1.86 mL	3.73 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Romeo Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 2015 PMID: 26102511
• Bonezzi An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis. J.Pharmacol.Exp.Ther. 2016 PMID: 26769918
• Ribeiro A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation. ACS Chem.Biol. 2015 PMID: 25874594

Product Documents for ARN 726