Artemisinin

Key Product Details

Product Description

Artemisinin is an antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (K_i ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

Product Specifications for Artemisinin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Artemisinin

The following data is based on the product molecular weight 282.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.71 mL	35.42 mL
5 mM	0.71 mL	3.54 mL	7.08 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Eckstein-Ludwig Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003 PMID: 12931192
• Wartenberg The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 2003 PMID: 14615418
• Balint Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 2001 PMID: 11578659

Product Documents for Artemisinin