Capillary Electrophoresis (CE) Instruments
Accelerate biotherapeutic development with Maurice and MauriceFlex Systems
Meet the Maurice Family
The Maurice capillary electrophoresis instruments empower your biologic development journey. Offering scalable solutions to analyze monoclonal antibodies (mAbs), viral particles, proteins, antibody drug conjugates (ADCs), and more, these systems deliver diverse applications, including:
- Protein charge analysis with imaged capillary isoelectric focusing (icIEF)
- Protein size and impurity measurement with capillary electrophoresis-SDS (CE-SDS)
- Charge isoform fraction collection with icIEF-based fractionation on the MauriceFlex for downstream characterization
icIEF technology for analyzing charge heterogeneity of therapeutic proteins includes:
- Whole-column imaging
- No extra mobilization step after focusing
- High resolution
- Quantitative data
- Minimal waste generation compared to HPLC
CE-SDS technology for analyzing the size and purity of therapeutic proteins includes
- Simplified sample prep and automated injection
- No acrylamide
- Quantitative data
- Minimal waste generation compared to SDS-PAGE
Biomolecular and Protein Fractionation on MauriceFlex enables deeper characterization of charge variants with fractionation
How it works:
- An applied electric field creates a pH gradient across the capillary inside the MauriceFlex cartridge
- Proteins separate by migrating to different pH values on the gradient, based on their individual isoelectric point (pI)
- Introduction of ammonium acetate chargers the pH gradient, mobilizing these separated proteins, and results in elution (fractionation)
Why Whole-Column Imaged Capillary Electrophoresis?
Whole column imaging, or imaged capillary isoelectric focusing (icIEF), saves you time and maintains resolution of peaks, in contrast to the extra mobilization step needed in conventional cIEF. Real-time imaging with icIEF also lets you troubleshoot and make necessary modifications during your run, thus saving you the need to repeat experiments.
eNewsletter
Stay up to date with the CE Chronicles eNewsletter. Read featured articles on biotherapeutic characterization, get the latest in industry news, learn about new products, discover what your peers are up to, and more.
Brochure
Get an overview of the different Maurice platforms, applications, and therapeutic modalities that they analyze.
Publications
See how Maurice systems are being implemented across a range of studies worldwide, from academia to industry.
Hear from Sara Carillo (NIBRT) talk about her lab’s experience with the MauriceFlex system, and how it accelerated the characterization of charge variants.
Since Dr. Christian Fercher from the Protein Expression Facility (PEF) at the University of Queensland in Australia adopted the Maurice instrument, their workflows have become significantly more accurate, efficient, and reproducible.
Read Xiaoping He’s (Pfizer) interview as she describes the benefits of icIEF technology and walks us through the transition process from the legacy iCE3 instrument to the Maurice system.
Looking for ProteinSimple Maurice Instruments?
Maurice and MauriceFlex capillary electrophoresis systems previously ProteinSimple are now R&D Systems. Following Bio-Techne's updated brand structure, ProteinSimple Maurice instruments are now part of the R&D Systems portfolio. You can now access the same trusted icIEF and CE-SDS technology, reagents, consumables, and technical support through rndsystems.com.
Celebrating CE Innovation: Past, Present, and Future
Watch our virtual event to get the latest news on Maurice Platforms. ProteinSimple is now R&D Systems, by Bio-Techne. Although our portfolio has a new name, you’ll still get the same innovative technologies, quality, support, and service. We share the many benefits of this change and provide resources supporting this transition.