AS 1269574

Key Product Details

Product Description

AS 1269574 is a GPR119 receptor agonist (EC₅₀ = 2.5 μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Orally available.

Product Specifications for AS 1269574

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AS 1269574

The following data is based on the product molecular weight 308.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.22 mL	32.45 mL
5 mM	0.65 mL	3.24 mL	6.49 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chepurny Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag. Mol.Endocrinol. 2013 PMID: 23798572
• Yoshida Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated Ins secretion. Biochem.Biophys.Res.Commun. 2010 PMID: 20804735

Product Documents for AS 1269574