Bengamide B

Key Product Details

Product Description

Bengamide B is a potent inhibitor of NF-κB activation (IC₅₀ = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.

Product Specifications for Bengamide B

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Bengamide B

The following data is based on the product molecular weight 598.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	83.50 mL	417.49 mL	834.99 mL
0.1 mM	16.70 mL	83.50 mL	167.00 mL
0.2 mM	8.35 mL	41.75 mL	83.50 mL
1 mM	1.67 mL	8.35 mL	16.70 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Johnson Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg.Med.Chem. 2012 PMID: 22705020
• Kinder Synthesis and antitumor activity of ester-modified analogues of bengamide B. J.Med.Chem. 2001 PMID: 11606134
• Hu Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem.Biol. 2007 PMID: 17656313

Product Documents for Bengamide B