C 87

Tocris Bioscience | Catalog # 5484

TNF-α inhibitor
Tocris Bioscience
Discontinued Product
5484 has been discontinued. View all Cytokine Compounds products.

Key Product Details

Description

TNF-α inhibitor
View all Cytokine Compounds »

Product Description

C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.

Product Specifications for C 87

Molecular Weight

502.93

Formula

C24H15ClN6O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]

CAS Number

332420-90-3

PubChem ID

5756872

InChI Key

VELQTEBILFDDQX-SLMZUGIISA-N

SMILES

O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.06 20

Preparing Stock Solutions for C 87

The following data is based on the product molecular weight 502.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.94 mL 49.71 mL 99.42 mL
1 mM 1.99 mL 9.94 mL 19.88 mL
2 mM 0.99 mL 4.97 mL 9.94 mL
10 mM 0.20 mL 0.99 mL 1.99 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for C 87

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for C 87

For research use only

Customer Reviews for C 87 (2)

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  • Combinatorial treatments
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2022
    Combinatorial treatments of the TNF-alpha inhibitor with chemotherapeutics led to synergistic apoptotic phenotype in vitro.
  • Works Well.
    Name: Purnima Gupta
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 01/10/2018
    Used in Fibroblast cytotoxicity assay

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