Chemical Name: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Biological ActivityCardamonin is a chalone analog that display anti-inflammatory activity. Inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera.
Lee et al.
Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood.
Ahmad et al.
Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells.
Israf et al.
Citations for Cardamonin
The citations listed below are publications that use Tocris products. Selected citations for Cardamonin include:
3 Citations: Showing 1 - 3
Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.
Authors: Kim Et al.
β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer.
Authors: Jia Et al.
Cell Death Differ 2015;22:298
Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins.
Authors: Yadav Et al.
Br J Pharmacol 2012;165:741
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