CCF 642

Tocris Bioscience | Catalog # 6063

Protein disulfide isomerase (PDI) inhibitor
Tocris Bioscience
Discontinued Product
6063 has been discontinued. View all Protein Disulphide Isomerase Inhibitors products.

Key Product Details

Description

Protein disulfide isomerase (PDI) inhibitor
View all Protein Disulphide Isomerase Inhibitors »

Product Description

CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.

Product Specifications for CCF 642

Molecular Weight

378.45

Formula

C15H10N2O4S3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone

CAS Number

346640-08-2

PubChem ID

1820764

InChI Key

SPYIETQLOVDJCF-XYOKQWHBSA-N

SMILES

COC1=CC=C(N2C(S/C(C2=O)=C/C3=CC=C([N+]([O-])=O)S3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.57 20

Preparing Stock Solutions for CCF 642

The following data is based on the product molecular weight 378.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.21 mL 66.06 mL 132.12 mL
1 mM 2.64 mL 13.21 mL 26.42 mL
2 mM 1.32 mL 6.61 mL 13.21 mL
10 mM 0.26 mL 1.32 mL 2.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CCF 642

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CCF 642

For research use only

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