Chlormethiazole hydrochloride
Chemical Name: 5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Purity: ≥99%
Biological Activity
Chlormethiazole hydrochloride is a sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity.
Cross et al.
Br.J.Pharmacol., 1995;114:1625 -
Chloromethiazole, dizocilpine and halope. prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats.
Hewitt and Green
Neuropharmacology, 1994;33:1589
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