CHM 1

Key Product Details

Product Description

Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G₂/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.

Product Specifications for CHM 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CHM 1

The following data is based on the product molecular weight 283.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.12 mL	70.61 mL	141.22 mL
1.25 mM	2.82 mL	14.12 mL	28.24 mL
2.5 mM	1.41 mL	7.06 mL	14.12 mL
12.5 mM	0.28 mL	1.41 mL	2.82 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tsai CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J.Biol.Chem. 2010 PMID: 20007968
• Wang CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol.Cancer.Ther. 2008 PMID: 18281518

Product Documents for CHM 1