Clomipramine hydrochloride
Chemical Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity: ≥98%
Biological Activity
Clomipramine hydrochloride is a potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a Ki of 0.05 nmol/l.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303 -
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Owens et al.
J.Pharmacol.Exp.Ther., 1997;283:1305 -
Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder.
McTavish and Benfield
Drugs, 1990;39:136 -
Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine.
Ortiz and Artiga
Br.J.Pharmacol., 1992;105:941 -
Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluox.
Ortiz and Artiga
Br.J.Pharmacol., 1992;105:941
Product Datasheets
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Citations for Clomipramine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Clomipramine hydrochloride include:
3 Citations: Showing 1 - 3
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Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
Authors: Conley Et al.
Eur J Neurosci 2015;352:53
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A translational rodent assay of affective biases in depression and antidepressant therapy.
Authors: Stuart Et al.
Neuropsychopharmacology 2013;38:1625
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The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
Authors: Duncan Et al.
J Biomed Sci 2010;31:1646
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