DMeOB

Key Product Details

Product Description

Negative allosteric modulator of the metabotropic glutamate receptor mGlu₅; displays reversible non-competitive inhibition of mGlu₅-mediated responses (IC₅₀ = 3 μM).

Product Specifications for DMeOB

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DMeOB

The following data is based on the product molecular weight 268.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.73 mL	18.64 mL	37.27 mL
5 mM	0.75 mL	3.73 mL	7.45 mL
10 mM	0.37 mL	1.86 mL	3.73 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• O'Brien A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 Mol.Pharmacol. 2003 PMID: 12920211

Product Documents for DMeOB