Domperidone

Key Product Details

Product Description

Domperidone is a peripheral dopamine D₂-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED₅₀ values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).

Product Specifications for Domperidone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Domperidone

The following data is based on the product molecular weight 425.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.74 mL	23.48 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.23 mL	1.17 mL	2.35 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Prakash and Wagstaff Domperidone. A review of its use in diabetic gastropathy. Drugs 1998 PMID: 9777316
• Osinski DA D₂, but not D₄, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 2005 PMID: 15894081
• Neimegeers The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int.Pharmacodyn.Ther. 1980 PMID: 7416883

Product Documents for Domperidone