Felbamate

Tocris Bioscience | Catalog # 0869

NMDA antagonist; acts at glycine site
Tocris Bioscience
Discontinued Product
0869 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description

NMDA antagonist; acts at glycine site
View all NMDA Receptor Antagonists »

Product Description

Felbamate is an anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.

Product Specifications for Felbamate

Molecular Weight

238.24

Formula

C11H14N2O4

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

2-Phenyl-1,3-propanedioldicarbamate

CAS Number

25451-15-4

PubChem ID

3331

InChI Key

WKGXYQFOCVYPAC-UHFFFAOYSA-N

SMILES

NC(=O)OCC(COC(N)=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.82 100
Ethanol 23.82 100

Preparing Stock Solutions for Felbamate

The following data is based on the product molecular weight 238.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.20 mL 20.99 mL 41.97 mL
5 mM 0.84 mL 4.20 mL 8.39 mL
10 mM 0.42 mL 2.10 mL 4.20 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Calculators

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Product Documents for Felbamate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Felbamate

For research use only

Customer Reviews for Felbamate (1)

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  • Block of NMDA receptor glycine site
    Name: Sergiy Sylantyev
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    Verified Customer | Posted 10/15/2020
    Felbamate was in use as an NMDA receptor antagonist affecting glycine site, to study (possible) competition of dopamine for this site. Application of felbamate and dopamine mixtures in different ratios resulted in a significant decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in DMSO. Illustration: the effect of 75% dopamine EC50 + 25% Felbamate EC50 on NMDA receptor single-channel openings (top trace); then 50%/50% and 25%/75% ratios.
    Felbamate 0869

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