Floxuridine

Key Product Details

Product Description

Floxuridine is an antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

Product Specifications for Floxuridine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Floxuridine

The following data is based on the product molecular weight 246.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.06 mL	20.31 mL	40.62 mL
5 mM	0.81 mL	4.06 mL	8.12 mL
10 mM	0.41 mL	2.03 mL	4.06 mL
50 mM	0.08 mL	0.41 mL	0.81 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Bapat Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 1983 PMID: 6220000
• Wyatt and Wilson Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 2009 PMID: 18979208
• Huehls Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 2012 PMID: 21613406

Product Documents for Floxuridine