G5

Key Product Details

Product Description

G5 is an ubiquitin isopeptidase inhibitor; activates caspases and apoptosis in an apoptosome-independent pathway.

Product Specifications for G5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for G5

The following data is based on the product molecular weight 414.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.83 mL	24.13 mL	48.26 mL
2.5 mM	0.97 mL	4.83 mL	9.65 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Foti Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system. Mol.Cancer Ther. 2009 PMID: 19887551
• Aleo Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 PMID: 16982768
• Hafner-Bratkovic NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat.Commun. 2018 PMID: 30518920

Product Documents for G5