Gabapentin

Key Product Details

Product Description

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca²⁺ channels. Prevents neuronal death and is antinociceptive and anxiolytic.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Gabapentin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Gabapentin

The following data is based on the product molecular weight 171.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

8 6 4 3 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.84 mL	29.20 mL	58.40 mL
5 mM	1.17 mL	5.84 mL	11.68 mL
10 mM	0.58 mL	2.92 mL	5.84 mL
50 mM	0.12 mL	0.58 mL	1.17 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Upton Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 1994 PMID: 7886818
• Taylor A summary of mechanistic hypotheses of gabap. pharmacology. Epilepsy Res. 1998 PMID: 9551785
• Timmerman A microdialysis study on the mechanism of action of gabap. Eur.J.Pharmacol. 2000 PMID: 10856447
• Fink Inhibition of Ca²⁺ influx by gabap. and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 2000 PMID: 10864898

Product Documents for Gabapentin