Gadolinium chloride

Key Product Details

Product Description

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.

Product Specifications for Gadolinium chloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Gadolinium chloride

The following data is based on the product molecular weight 263.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.79 mL	18.97 mL	37.93 mL
5 mM	0.76 mL	3.79 mL	7.59 mL
10 mM	0.38 mL	1.90 mL	3.79 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Nagata The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 18162548
• Lee The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca²⁺ and cAMP. Nature 2012 PMID: 23143333
• Del Favero The stretch-activated channel blocker Gd³⁺ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 2012 PMID: 22900474
• Nishitani Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 2011 PMID: 22053183

Product Documents for Gadolinium chloride