GANT 58
Chemical Name: 2,3,4,5-Tetra(4-pyridyl)thiophene
Purity: ≥99%
Biological Activity
GANT 58 is a GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Lauth et al.
Proc.Natl.Acad.Sci., 2007;104:8455 -
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
Beauchamp et al.
J.Biol.Chem., 2009;284:9074 -
GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.
Joo et al.
PLoS ONE, 2009;4:7608
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for GANT 58
The citations listed below are publications that use Tocris products. Selected citations for GANT 58 include:
1 Citation: Showing 1 - 1
-
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
Authors: Oladapo
Cancer Lett 2017;411:136
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for GANT 58
There are currently no reviews for this product. Be the first to review GANT 58 and earn rewards!
Have you used GANT 58?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
