GANT 58

Key Product Details

Product Description

GANT 58 is a GLI antagonist that inhibits GLI1-induced transcription (IC₅₀ = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.

Product Specifications for GANT 58

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GANT 58

The following data is based on the product molecular weight 392.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.19 mL	50.96 mL	101.92 mL
1.25 mM	2.04 mL	10.19 mL	20.38 mL
2.5 mM	1.02 mL	5.10 mL	10.19 mL
12.5 mM	0.20 mL	1.02 mL	2.04 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Beauchamp GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J.Biol.Chem. 2009 PMID: 19189974
• Joo GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 2009 PMID: 19859563
• Lauth Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 2007 PMID: 17494766

Product Documents for GANT 58