HexylHIBO

Key Product Details

Product Description

HexylHIBO is a group I mGlu receptor antagonist (K_i values are 140 and 110 μM at mGlu_1a and mGlu_5a receptors respectively). Decreases sEPSCs in rat pyramidal neurons in vitro.

S-enantiomer also available.

Product Specifications for HexylHIBO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for HexylHIBO

The following data is based on the product molecular weight 256.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	19.51 mL	97.54 mL	195.08 mL
1 mM	3.90 mL	19.51 mL	39.02 mL
2 mM	1.95 mL	9.75 mL	19.51 mL
10 mM	0.39 mL	1.95 mL	3.90 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Madsen Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J.Med.Chem. 2001 PMID: 11297452
• Bandrowski Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J.Neurophysiol. 2003 PMID: 12626613

Product Documents for HexylHIBO