(±)-HIP-B

Key Product Details

Product Description

Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [³H]D-aspartate release (IC₅₀ = 1.2 μM) rather than [³H]L-glutamate uptake (IC₅₀ = 16.9 μM). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC₅₀ values are 35 and 45 μM respectively).

Product Specifications for (±)-HIP-B

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-HIP-B

The following data is based on the product molecular weight 172.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	29.05 mL	145.23 mL	290.46 mL
1 mM	5.81 mL	29.05 mL	58.09 mL
2 mM	2.90 mL	14.52 mL	29.05 mL
10 mM	0.58 mL	2.90 mL	5.81 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Funicello Dissociation of [3H]glutamate uptake from glutamate-induced [3H]D-Aspartate release by 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid and 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrro Mol.Pharmacol. 2004 PMID: 15322243
• Conti Synthesis of new bicyclic analogues of glutamic acid. Tetrahedron
• Conti Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists. J.Med.Chem. 1999 PMID: 10514280

Product Documents for (±)-HIP-B