Home / JNK/c-jun Inhibitors / IQ 3

IQ 3

Catalog #: 4550
1 Citation Datasheet / COA / SDS

Discontinued Product

4550 has been discontinued.
View all JNK/c-jun Inhibitors products.
IQ 3 | CAS No. 312538-03-7 | JNK/c-jun Inhibitors
1 Image
Description: Selective JNK3 inhibitor

Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.

Technical Data

M.Wt:
341.32
Formula:
C20H11N3O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
312538-03-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
    Schepetkin et al.
    Mol.Pharmacol., 2012;81:832

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for IQ 3

The citations listed below are publications that use Tocris products. Selected citations for IQ 3 include:

1 Citation: Showing 1 - 1

  1. Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex.
    Authors: Easton Et al.
    J Neurosci  2014;34:3854

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for IQ 3

There are currently no reviews for this product. Be the first to review IQ 3 and earn rewards!

Have you used IQ 3?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.