Isoginkgetin

Key Product Details

Product Description

Isoginkgetin is a pre-mRNA splicing inhibitor (IC₅₀ ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable

Product Specifications for Isoginkgetin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Isoginkgetin

The following data is based on the product molecular weight 566.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.83 mL	17.65 mL
5 mM	0.35 mL	1.77 mL	3.53 mL
10 mM	0.18 mL	0.88 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Szewczak The right tool for the job. Cell 2017 PMID: 28475886
• Boswell Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat.Chem.Biol. 2017 PMID: 28263964
• O'Brien The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J.Biol.Chem. 2008 PMID: 18826947

Product Documents for Isoginkgetin