KM 11060

Tocris Bioscience | Catalog # 3143

Corrects F508del-CFTR trafficking
Tocris Bioscience
Discontinued Product
3143 has been discontinued. View all Other CFTR Compounds products.

Key Product Details

Description

Corrects F508del-CFTR trafficking
View all Other CFTR Compounds »

Product Description

KM 11060 is a corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.

Product Specifications for KM 11060

Molecular Weight

422.33

Formula

C19H17Cl2N3O2S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

CAS Number

774549-97-2

PubChem ID

1241327

InChI Key

GIEHIZKCIZLXLF-UHFFFAOYSA-N

SMILES

ClC(C=C4)=CC=C4S(N(CC3)CCN3C1=CC=NC2=C1C=CC(Cl)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.23 100
Ethanol 4.22 10

Preparing Stock Solutions for KM 11060

The following data is based on the product molecular weight 422.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.68 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for KM 11060

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KM 11060

For research use only

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