LOE 908 hydrochloride

Name: LOE 908 hydrochloride
Brand: Tocris Bioscience
SKU: 2314
Price: 201 USD

Catalog #: 2314
2 Citations Datasheet / COA / SDS

Discontinued Product

2314 has been discontinued.

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LOE 908 hydrochloride | CAS No. 143482-60-4 | Ion Channel Modulators

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Description: Broad spectrum cation channel blocker; neuroprotective

Chemical Name: 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity

LOE 908 hydrochloride is a broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na⁺ and K⁺ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

Technical Data

M.Wt:

749.29

Formula:

C₄₁H₄₈N₂O₉.HCl

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

143482-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study.
Christensen et al.
Basic Clin.Pharmacol.Toxicol., 2005;96:316
LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture.
Krause et al.
Biochem.Biophys.Res.Comm., 1998;244:659
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat.
Tatlisumak et al.
J.Neurol.Sci., 2000;178:107

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Citations for LOE 908 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for LOE 908 hydrochloride include:

2 Citations: Showing 1 - 2

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
Authors: Varadarajan Et al.
PLoS One 2013;8:e56603
Protein kinase Ctheta negatively regulates store-independent Ca²⁺ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets.
Authors: Harper and Poole
J Biol Chem 2010;285:19865

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