M62812

Tocris Bioscience | Catalog # 5705

TLR-4 inhibitor
Tocris Bioscience
Discontinued Product
5705 has been discontinued. View all Toll-like Receptor Inhibitors products.

Key Product Details

Description

TLR-4 inhibitor
View all Toll-like Receptor Inhibitors »

Product Description

M62812 is a TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Product Specifications for M62812

Molecular Weight

330.23

Formula

C13H11N3OS.2HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride

CAS Number

613263-00-6

PubChem ID

44224214

InChI Key

SMTKPLISDFNJDJ-UHFFFAOYSA-N

SMILES

NC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.02 100
DMSO 16.51 50

Preparing Stock Solutions for M62812

The following data is based on the product molecular weight 330.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.28 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.30 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.30 mL 0.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for M62812

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for M62812

For research use only

Customer Reviews for M62812 (1)

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  • Ok, needs titrations
    Name: Scott Scarneo
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: THP-1
    Verified Customer | Posted 02/06/2019
    We were interested in looking at LPS TLR4 mediated signaling and were hoping to use this to block this.
    M62812 5705

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