(-)-Cotinine

Key Product Details

Product Description

Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.

Product Specifications for (-)-Cotinine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (-)-Cotinine

The following data is based on the product molecular weight 176.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.67 mL	28.37 mL	56.75 mL
5 mM	1.13 mL	5.67 mL	11.35 mL
10 mM	0.57 mL	2.84 mL	5.67 mL
50 mM	0.11 mL	0.57 mL	1.13 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Terry Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 2005 PMID: 16389292
• Echeverria Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 2011 PMID: 20930295
• Buccafusco and Terry The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 2003 PMID: 12706481

Product Documents for (-)-Cotinine