ML 349

Key Product Details

Product Description

ML 349 is a selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC₅₀ = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC₅₀ values are >3000 and >10,000 nM respectively).

Product Specifications for ML 349

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 349

The following data is based on the product molecular weight 454.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.00 mL	55.00 mL	110.00 mL
1 mM	2.20 mL	11.00 mL	22.00 mL
2 mM	1.10 mL	5.50 mL	11.00 mL
10 mM	0.22 mL	1.10 mL	2.20 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Hernandez APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Che.Bio. 2017 PMID: 28065656
• Adibekian Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 24624468

Product Documents for ML 349