NQTrp

Key Product Details

Product Description

NQTrp is a potent inhibitor of Aβ oligomer and fibril formation (IC₅₀ = 50 nM for formation of fibrils from Aβ1-42). Reduces cytotoxicity of Aβ oligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ1-42.

Product Specifications for NQTrp

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NQTrp

The following data is based on the product molecular weight 360.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.88 mL	27.75 mL
5 mM	0.56 mL	2.78 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Scherzer-Attali Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. PLoS ONE 2010 PMID: 20559435
• Zhang Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem.Neurosci. 2013 PMID: 24246047

Product Documents for NQTrp