PALDA

Key Product Details

Product Description

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB₁ receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC₅₀ > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC₅₀ from ~ 90 to ~ 30 nM.

Product Specifications for PALDA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PALDA

The following data is based on the product molecular weight 391.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	51.07 mL	255.37 mL	510.74 mL
0.25 mM	10.21 mL	51.07 mL	102.15 mL
0.5 mM	5.11 mL	25.54 mL	51.07 mL
2.5 mM	1.02 mL	5.11 mL	10.21 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• De Petrocellis Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 2004 PMID: 15289293
• Chu N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 2003 PMID: 12569099

Product Documents for PALDA