Parthenolide

Tocris Bioscience | Catalog # 0610

5-HT release inhibitor
Tocris Bioscience
Discontinued Product
0610 has been discontinued. View all Additional 5-HT-Related Compounds products.

Key Product Details

Description

5-HT release inhibitor
View all Additional 5-HT-Related Compounds »

Product Description

The active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B4 and thromboxane B2.

Product Specifications for Parthenolide

Molecular Weight

248.32

Formula

C15H20O3

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

[1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

CAS Number

20554-84-1

PubChem ID

6473881

InChI Key

KTEXNACQROZXEV-SLXBATTESA-N

SMILES

C/C1=C\CC[C@]2(C)[C@@H](O2)[C@@H](OC([C@]3=C)=O)[C@H]3CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.42 100

Preparing Stock Solutions for Parthenolide

The following data is based on the product molecular weight 248.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.40 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.40 mL 0.81 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Parthenolide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Parthenolide

For research use only

Customer Reviews for Parthenolide (1)

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  • Parthenolide as a behavioral cocaine antagonist
    Name: One Pagan
    Species: Planaria
    Assay Type: In Vivo
    Verified Customer | Posted 01/10/2018
    I have used Tocris’ Parthenolide (Cat. No. 0610) for a few years in my research program searching for behavioral antagonists of cocaine. This research has resulted in 5 peer-reviewed papers and the discovery story is included in a chapter of my book The First Brain: The Neuroscience of Planarians and in a review paper (shown in the figure). There are at least 4 more papers in preparation and the project is still going strong. In the initial phases of my project, I evaluated several suppliers of parthenolide and Tocris’ offering consistently came ahead in terms of customer service and compound purity, and I do not intend to change suppliers. I recommend this product and the company without reservation.
    Behavioral evaluation of antagonistic effects of parthenolide on cocaine effects in planarians
    Parthenolide 0610

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