Parthenolide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β.
   Hehner et al.
   J.Biol.Chem., 1998;273:1288
3. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro.
   Groenewegen and Heptinstall
   J.Pharm.Pharmacol., 1990;42:553
4. Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit.
   Heptinstall et al.
   J.Pharm.Pharmacol., 1986;38:709
5. Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components.
   Sumner et al.
   Biochem.Pharmacol., 1992;43:2313

Product Datasheets