PBIT

Key Product Details

Product Description

PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC₅₀ values are 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. Inhibits proliferation of breast cancer cell lines expressing high levels of JARIDB1.

Product Specifications for PBIT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PBIT

The following data is based on the product molecular weight 241.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.14 mL	20.72 mL	41.44 mL
5 mM	0.83 mL	4.14 mL	8.29 mL
10 mM	0.41 mL	2.07 mL	4.14 mL
50 mM	0.08 mL	0.41 mL	0.83 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sayegh Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J.Biol.Chem. 2013 PMID:  23408432

Product Documents for PBIT