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PF 3716556

Catalog #: 4191 Datasheet / COA / SDS

Discontinued Product

4191 has been discontinued.
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PF 3716556 | CAS No. 928774-43-0 | H+/K+ ATPase Inhibitors
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Description: Selective H+,K+-ATPase inhibitor

Chemical Name: 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide

Purity: ≥98%

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Biological Activity

PF 3716556 is a H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays); more potent in acidic conditions. Highly selective for H+,K+-ATPase in vitro; displays no activity at Na+,K+-ATPase. Also displays selectivity for H+,K+-ATPase over a range of 50 receptors and ion channels (IC50 > 10 μM). Inhibits gastric acid secretion in rat and dog models.

Technical Data

M.Wt:
394.47
Formula:
C22H26N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
928774-43-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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