Pluripotin

Key Product Details

Product Description

Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).

Product Specifications for Pluripotin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Pluripotin

The following data is based on the product molecular weight 550.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.27 mL	36.33 mL	72.66 mL
1.25 mM	1.45 mL	7.27 mL	14.53 mL
2.5 mM	0.73 mL	3.63 mL	7.27 mL
12.5 mM	0.15 mL	0.73 mL	1.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen Self-renewal of embryonic stem cells by a small molecule. Proc.Natl.Acad.Sci.USA 2006 PMID: 17088537
• Mertins A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One 2013 PMID: 23437320
• Wu and Ding Applying chemical tools to the discovery of novel regenerative medicine. Drug Discov.Today Technol.

Product Documents for Pluripotin