PM 226

Tocris Bioscience | Catalog # 6220

Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective
Tocris Bioscience
Discontinued Product
6220 has been discontinued. View all Cannabinoid R2/CB2 Agonists products.

Key Product Details

Description

Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective
View all Cannabinoid R2/CB2 Agonists »

Product Description

PM 226 is a potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective.

Product Specifications for PM 226

Molecular Weight

357.49

Formula

C22H31NO3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-(1,1-Dimethylheptyl)-9-methoxy-4,4-dimethyl-4H-[1]benzopyrano[3,4-d]isoxazole

CAS Number

1949726-13-9

PubChem ID

132510986

InChI Key

VFWIRWAAMNBBFG-UHFFFAOYSA-N

SMILES

CCCCCCC(C)(C1=CC(OC)=C2C3=C(C(C)(OC2=C1)C)C=NO3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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Product Documents for PM 226

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PM 226

For research use only

Related Research Areas

Bioactive Lipids and Receptors

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