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ProTx III

Catalog #: 5792 Datasheet / COA / SDS

Discontinued Product

5792 has been discontinued.
View all Voltage-gated Sodium Channel Blockers products.
ProTx III
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Description: Potent Nav1.7 blocker; analgesic
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Biological Activity

ProTx III is a potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 at Nav1.7.

Technical Data

M.Wt:
3802.41
Formula:
C162H246N52O43S6
Sequence:
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI

(Modifications: Disulfide bridge: 2-17, 9-22, 16-29, Ile-33 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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