PTAC oxalate

Key Product Details

Product Description

PTAC oxalate is a muscarinic receptor ligand. Displays partial agonist activity at M₂ and M₄ receptors; exhibits antagonist effects at M₁, M₃ and M₅ receptors (K_i values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.

Product Specifications for PTAC oxalate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PTAC oxalate

The following data is based on the product molecular weight 359.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.91 mL	27.82 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Shannon Muscarinic receptor agonists, like DA receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats. J.Pharmacol.Exp.Ther. 1999 PMID: 10411607
• Bymaster Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane. Eur.J.Pharmacol. 1998 PMID: 9774240
• Raedler Towards a muscarinic hypothesis of schizophrenia. Mol.Psychiatry 2007 PMID: 17146471

Product Documents for PTAC oxalate