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Qc 1

Catalog #: 5055 Datasheet / COA / SDS

Discontinued Product

5055 has been discontinued.
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Qc 1 | CAS No. 403718-45-6 | Dehydrogenase Inhibitors
1 Image
Description: Metabolite

Chemical Name: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

Purity: ≥98%

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Biological Activity

Qc 1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM). Induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells.

Technical Data

M.Wt:
455.45
Formula:
C23H16F3N3O2S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
403718-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Targeted killing of a mammalian cell based upon its specialized metabolic state.
    Alexander et al.
    Proc.Natl.Acad.Sci.USA, 2011;108:15828

Product Datasheets

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