Qc 1

Tocris Bioscience | Catalog # 5055

Metabolite
Tocris Bioscience
Discontinued Product
5055 has been discontinued. View all Dehydrogenase Inhibitors products.

Key Product Details

Description

Metabolite

Product Description

Qc 1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM). Induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells.

Product Specifications for Qc 1

Molecular Weight

455.45

Formula

C23H16F3N3O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

CAS Number

403718-45-6

PubChem ID

5000754

InChI Key

IFNVTSPDMUUAFY-UHFFFAOYSA-N

SMILES

O=C(N2C3=CC(C(F)(F)F)=CC=C3)C1=CC=C(C(NCC4=CC=CC=C4)=O)C=C1NC2=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.77 50

Preparing Stock Solutions for Qc 1

The following data is based on the product molecular weight 455.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.39 mL 21.96 mL 43.91 mL
2.5 mM 0.88 mL 4.39 mL 8.78 mL
5 mM 0.44 mL 2.20 mL 4.39 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Qc 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Qc 1

For research use only

Related Research Areas

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