(-)-Quinpirole hydrochloride

Tocris Bioscience | Catalog # 1061

Selective D2-like agonist
Tocris Bioscience

Key Product Details

Description

Selective D2-like agonist
View all Non-selective Dopamine Receptor Agonists »

Product Description

(-)-Quinpirole hydrochloride is a selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).

Licensing Information

Sold with the permission of Eli Lilly and Company

Product Specifications for (-)-Quinpirole hydrochloride

Molecular Weight

255.79

Formula

C13H21N3.HCl

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

(4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride

CAS Number

85798-08-9

PubChem ID

55397

InChI Key

HJHVRVJTYPKTHX-HTMVYDOJSA-N

SMILES

Cl.[H][C@]12CCCN(CCC)[C@]1([H])CC1=CNN=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.58 100
DMSO 6.39 25

Preparing Stock Solutions for (-)-Quinpirole hydrochloride

The following data is based on the product molecular weight 255.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.91 mL 19.55 mL 39.09 mL
5 mM 0.78 mL 3.91 mL 7.82 mL
10 mM 0.39 mL 1.95 mL 3.91 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 141 publications citing the usage of this product.

Product Documents for (-)-Quinpirole hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (-)-Quinpirole hydrochloride

For research use only

Citations for (-)-Quinpirole hydrochloride

Customer Reviews for (-)-Quinpirole hydrochloride (2)

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  • Inhibition of Synaptic Transmission in the VP
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/02/2020
    quinpirole(1 μΜ)
    (-)-Quinpirole hydrochloride 1061
  • Quinpirole reduces evoked dopamine release
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 03/28/2018
    Goes into water well. We usually make up a 1 mM stock for many experiments.
    Voltammetry experiments were used to measure evoked dopamine release. Quinpirole (30nM) reduces dopamine release considerably (near IC50 in dorsal striatum), which was reversed by sulpiride (600nM). Drug works every time!
    (-)-Quinpirole hydrochloride 1061

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