Radicicol

Key Product Details

Product Description

Radicicol is an antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Product Specifications for Radicicol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Radicicol

The following data is based on the product molecular weight 364.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.41 mL	137.07 mL	274.14 mL
0.5 mM	5.48 mL	27.41 mL	54.83 mL
1 mM	2.74 mL	13.71 mL	27.41 mL
5 mM	0.55 mL	2.74 mL	5.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

• Oikawa Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 1993 PMID: 7694864
• Schulte Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 1999 PMID: 10478836
• Lee Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 2002 PMID: 11911945

Product Documents for Radicicol