SB 221284

Key Product Details

Product Description

SB 221284 is a potent, selective 5-HT_2C/2B receptor antagonist. pK_i values are 6.4, 7.9 and 8.6 for 5-HT_2A, _2B and _2C receptors respectively. Centrally active upon systemic administration in vivo.

Licensing Information

Sold under license

Product Specifications for SB 221284

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 221284

The following data is based on the product molecular weight 353.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bromidge Novel and selective 5-HT_2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. J.Med.Chem. 1998 PMID: 9572885
• Hutson Activation of mesolimbic DA function by phencyclidine is enhanced by 5-HT_2C/2B receptor antagonists: neurochemical and behavioural studies. Neuropharmacology 2000 PMID: 10974315
• Bristow Evidence for accelerated desensitisation of 5-HT_2C receptors following combined treatment with fluox. and the 5-HT_1A receptor antagonist, WAY 100,635, in the rat. Neuropharmacology 2000 PMID: 10760364

Product Documents for SB 221284