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Scrambled 10Panx

Catalog #: 3708
4 Citations Datasheet / COA / SDS

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Scrambled 10Panx
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Description: Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide
Alternative Names: scPanx
Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Scrambled 10Panx is a scrambled version of 10Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. 10Panx also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Technical Data

M.Wt:
1242.37
Formula:
C58H79N15O16
Sequence:
FSVYWAQADR
Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Store at -20°C
CAS No:
1315378-72-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process.
    Melhorn M, Brodsky A, Estanislau J, Khoory J, Illigens B, Hamachi I, Kurishita Y, Fraser A, Nicholson-Weller A, Dolmatova E, Duffy H, Ghiran I
    J Biol Chem, 2013;288(43):31139-53.
  2. Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis
    J Boucher, C Simonneau, G Denet, J Clarhaut, AC Balandre, M Mesnil, L Cronier, A Monvoisin
    Int J Mol Sci, 2018;19(6):.
  3. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
    L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello
    Cell Rep, 2018;25(11):3059-3073.e10.
  4. The P2X7 Receptor Primes IL-1? and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
    F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell
    Front Cell Neurosci, 2017;11(0):227.
  5. Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis
    W Chen, S Zhu, Y Wang, J Li, X Qiang, X Zhao, H Yang, J D'Angelo, L Becker, P Wang, KJ Tracey, H Wang
    Sci Rep, 2019;9(1):160.
  6. Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.
    Wang et al.
    Am.J.Physiol.Cell Physiol., 2007;293:C1112
  7. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.
    Thompson et al.
    Science, 2008;322:1555
  8. Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor.
    Pelegrin and Surprenant
    EMBO J., 2006;25:5071

Product Datasheets

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Citations for Scrambled 10Panx

The citations listed below are publications that use Tocris products. Selected citations for Scrambled 10Panx include:

4 Citations: Showing 1 - 4

  1. Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis.
    Authors: Chen Et al.
    Sci Rep  2019;9:160
  2. Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.
    Authors: Hudson Et al.
    J Pharmacol Exp Ther  2019;370:44
  3. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  4. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.
    Authors: Albalawi Et al.
    Front Cell Neurosci  2017;11:227

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